Typically, a drug’s half-life (the amount of time it takes for one half of its concentration to be eliminated from the body) is a few hours. But Vyvanse has a short half-life of only 47 minutes. This means that the drug is gone in less than an hour, making it difficult to determine how long Vyvanse takes to work.
Factors that affect the half-life of Vyvanse
The half-life of Vyvanse depends on a number of factors, including its use, dose, and time of administration. If you are taking the drug for a long time, it might affect your liver function. This can lead to an adverse reaction known as serotonin syndrome, which is potentially life-threatening and is associated with other drugs that affect the serotonergic system. These drugs include triptans, lithium, tramadol, and fentanyl.
The clearance of Vyvanse varies from person to person. Clearance time depends on age, body mass, and renal function. The amount of drug that remains in the bloodstream can increase when a person takes the drug frequently. High-frequency users tend to build up tolerance to high doses. Therefore, their half-life will be longer than those who take the drug infrequently.
In clinical trials of Vyvanse in adults, adverse reactions were reported in 6% of the patients and in 2% of placebo-treated patients. Adverse reactions most commonly reported in patients included blurred vision, anxiety, and tachycardia. Other less common symptoms of Vyvanse use included headache, dysgeusia, and irritability. Although rare, side effects are important to monitor during treatment.
Insomnia is another possible Vyvanse side effect. While most stimulant drugs cause insomnia, some individuals may experience it even if they do not suffer from this condition. This condition can be particularly disturbing in children. The good news is that it generally resolves itself after an adjustment period. However, this problem may persist or become worse once the dose is reduced or the patient discontinues Lisdexamfetamine.
Other serious side effects of Vyvanse include a potentially life-threatening condition called serotonin syndrome. While serotonin syndrome occurs with other medicines, Vyvanse should be discontinued as soon as possible if the patient develops the symptoms. Symptoms of serotonin syndrome may include agitation, flushing, fast heartbeat, loss of coordination, and high body temperature. Seizures and tremors may also occur.
Drug interactions with other drugs
There are various Vyvanse drug interactions with other medications, including alcohol and caffeine. The list of interactions is not complete, but it does show that Vyvanse may affect certain foods and medical conditions. While the list of drug interactions may not be comprehensive, these interactions are significant enough to warrant a careful review by a healthcare provider. If a medication is prescribed for a specific condition, it should not be combined with other medications unless they are completely unrelated.
Serotonin syndrome may occur when VYVANSE is combined with other antidepressants or serotonergic drugs. Examples of such drugs include SSRIs, SNRIs, triptans, and tricyclic antidepressants. Serotonin-stimulating drugs such as lithium, tramadol, and tryptophan may also increase the risk of serotonin syndrome.
The heightened risk of addiction from stimulant drugs like Vyvanse is particularly concerning for adults. A new definition of BED in the Diagnostic and Statistical Manual of Mental Disorders, or DSM-5, has reclassified BED as an adult condition. Because adults are more likely to abuse stimulant medications, they are often more susceptible to addiction. And while the drug may have a lower rate of addiction than other similar drugs, the risk of addiction still remains significant.
The effects of Vyvanse on the brain increase the production of the neurotransmitter dopamine. Dopamine plays a central role in the brain’s reward pathway, where addiction takes hold. As dopamine levels rise, the brain’s reward system remembers that particular behavior caused a high level of dopamine, creating the perception that a drug is necessary to feel good. Over time, this need grows stronger and more severe. Listed below are core risk factors for Vyvanse addiction.